Comparison of mechanism of action: anticholinergics, short-acting β 2 -agonists and long-acting β 2 -agonists Anticholinergics have a different mechanism of action compared with short-acting β 2 -agonists (SABAs) and LABAs, which bind to airway β 2 -receptors to trigger smooth muscle relaxation [ 69, 70 ]. 2015 Jun 27. Action of beta2 agonists These work by binding to beta2 receptors in airway smooth muscle. Deeks SG, Kar S, Gubernick SI, Kirkpatrick P. Fresh from the pipeline: raltegravir. May 13, 2003. 15(Suppl 4):18112: Gallant J, Lazzarin A, Mills A, et al. Eshleman SH, Hudelson SW, Redd AD, et al. 316(2):191-210. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Later, tiotropium also became available as an inhalation spray delivered via a soft mist inhaler (SMI). Elvitegravir clinical trials. Available at https://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. 1998. A muscarinic receptor antagonist (MRA) is a type of anticholinergic agent that blocks the … [20] The safety and efficacy profiles of both devices are comparable and people's preference should play a role in determining inhaler choice. N Engl J Med. TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments. March, 2018. Available at https://stacks.cdc.gov/view/cdc/20711. There is an increase in cyclic adenosine monophosphate (cyclic AMP) in the cells. Baeten JM, Donnell D, Nase P, et al. 2008. 2014 Apr 9. (epub ahead of print). Lancet. Atomic structure of the ectodomain from HIV-1 gp41. Lama Nazzal. Aaron Glatt, MD Chairman, Department of Medicine, Chief, Division of Infectious Diseases, Hospital Epidemiologist, South Nassau Communities Hospital 2018 May 30; Accessed: 2018 Jun 27. Long-term monitoring of genotypic and phenotypic resistance to T20 in treated patients infected with HIV-1. FDA News Release. Hughes A, Barer T, Nelson M. New treatment options for HIV salvage patients: an overview of second generation PIs, NNRTIs, integrase inhibitors and CCR5 antagonists. February 13-16, 2017. These novel drugs work by blocking the action of leukotrienes. Buti M, Gane E, Seto WK, et al. HCV guidance: recommendations for testing, managing, and treating hepatitis C. hcvguidelines.org. 350:1023-1035. 2002. DeJesus E, Rockstroh JK, Henry K, Molina JM, Gathe J, Ramanathan S, et al. Guidelines for the use of antiretroviral agents in adults and adolescents living with HIV. Jones G, Ledford R, Yu F, et al. Once bound to the receptor, they set in progress a complicated chain of events, similar to that produced by the action of the natural neurotransmitters. 2006. 171(11):1063-1071. J Hepatol. 2016 Jul 12. 2017 Nov 4. Mortality and causes of death in people diagnosed with HIV in the era of highly active antiretroviral therapy compared with the general population: an analysis of a national observational cohort. • PMhx: HTN • Social Hx: ETOH abuse 1L of hard liquor/day, Non smoker, no … Princeton, NJ: Bristol-Myers Squibb. Lancet HIV. [Medline]. Clin Pharmacokinet. Prevention of HIV-1 infection with early antiretroviral therapy. Lancet HIV. N Engl J Med. Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an international AIDS society—USA panel. [4] It is used by inhalation through the mouth. Learn more about Gamma-Aminobutyric Acid (Gaba) uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Gamma-Aminobutyric Acid (Gaba) 25 (1s):4s-446s. 33:562-569. Furthermore, … ClinicalTrials.gov. Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study. Protease inhibitor resistance update: where are we now?. 2003. 371:1417-1426. Back in 2009, Franson and Cohen started an occasional series of short reviews of drugs with new mechanisms of action, highlighting new pharmacological discoveries. [20] There is no significant difference in all-cause mortality between tiotropium soft mist inhalers compared to dry powder inhalers, however caution needs to be taken in people with severe heart or kidney problems. Lancet. Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. Evaluation of the genotypic prediction of HIV-1 coreceptor use versus a phenotypic assay and correlation with the virological response to maraviroc: the ANRS GenoTropism study. [Medline]. 2000. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. 2008. 2018 May 23; Accessed: 2018 Jun 26. Peginterferon alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons. 2008. Department of Health and Human Services. Abstract 789. Expert Opin Drug Metab Toxicol. February 25-28, 2007. Lancet. Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC. Metabolism and disposition in humans of raltegravir (MK-0518) an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme. Alter M. Epidemiology of viral hepatitis and HIV co-infection. Sax PE, Wohl D, Yin MT, et al. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. 3:237-248. [4] In September 2008 a review found that tiotropium and another member of its class ipratropium may be linked to increased risk of heart attacks, stroke and cardiovascular death. 51(8):963-72. [Medline]. AIDSinfo. 381(9883):2083-90. [Medline]. 2003. (epub ahead of print). HIV integrase is responsible for the transport and attachment of proviral DNA to host-cell chromosomes, allowing transcription of viral proteins and subsequent assembly of virus particles. [Medline]. Castagna A, Maggiolo F, Penco G, et al. Seattle, WA. Clin Pharmacokinet. The role of LAMA such as tiotropium bromide has only recently been established in those with asthma, whereas in COPD, it is a first-line LABD. Available at http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4314b1-01-Merck.pdf. 6:427-433. [Guideline] Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission. 2017 September 21; Accessed: 2018 Jun 18. J Infect Dis. HIV Drug Resistance. Clin Infect Dis. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. LAMA/LABAs provide a more comprehensive approach to bronchodilation through 2 mechanisms of action — LAMAs decrease bronchoconstriction, LABAs promote bronchodilation 1,2 *Based on IMS Monthly NPA data reporting total prescriptions for LAMA, ICS/LABA, LAMA/LABA, LABA, SABA, SAMA, SABA/SAMA for a 6-month time period ending February 2017 vs February 2018 . N Engl J Med. 2001. June 9-13, 2009. [Medline]. Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. Chan HLY, Fung S, Seto WK, et al. Resistance to the HIV-integrase inhibitor raltegravir: analysis of protocol 005, a phase II study in patients with triple-class resistant HIV-1 infection. 74(1):112-116. Curr HIV Res. [Medline]. [Medline]. 2004. [Medline]. 2013 Feb. 41(2):353-61. JAMA Pediatr. 2015 Jul 20. [Medline]. Abstract 9. Choopanya K, Martin M, Suntharasamai P, et al. 47:266-285. 322(7299):1410-2. 2005. [Medline]. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. [Medline]. 2004. 59:342-346. Kottler DP. Case • 46 yo CM with PMHx of HTN, ETOH abuse presenting thirty minutes after ingesting 50 tablets of full strength ASA (16.25g). The SMI was designed to overcome or … Crossref. Lancet. Abstract Umeclidinium/vilanterol (Anoro ElliptaTM; LaventairTM) is an inhaled fixed-dose combination of a long-acting muscarinic receptor antagonist and a long- acting b 2-adrenoceptor agonist. 2002. Top Antivir Med. Clin Infect Dis. [Medline]. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial. Expert Rev Anti-infect Ther. 2013 Mar 27. [Medline]. Drug Metab Dispos. Dolutegravir (DTG; S/GSK1349572) + Abacavir/Lamivudine Once Daily Statistically Superior to Tenofovir/Emtricitabine/Efavirenz: 48-Week Results - SINGLE (ING114467). [Medline]. 2008. [Guideline] European AIDS Clinical Society. XVIII International Drug Resistance Workshop. 2015 Oct. 59 (10):5909-16. 2002. Recommendations for the use of antiretroviral drugs in pregnant women with HIV infection and interventions to reduce perinatal HIV transmission in the United States. Lancet Public Health. 338:1281-1293. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. 46:716-723. Montreal, Quebec Canada: Theratechnologies. Available at https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-treatment-guidelines/0. [Medline]. 390(10107):2073-82. HIV-1 protease mutations and protease inhibitor cross-resistance. 8(5):e63623. Seattle, Washington. R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP Professor and Chair, Department of Clinical and Administrative Sciences, College of Pharmacy, Adjunct Professor of Medicine (Infectious Diseases), University of Oklahoma Health Sciences Center 2010 Oct. 54(10):4253-61. [Medline]. 2008. [Medline]. 4:979-90. Available at [Full Text]. [14] A 2006 review found the increase in bronchospasm was small and did not reach statistical significance. 2016 Jul 12. LABA combinations with inhaled corticosteroids are usually reserved for patients with severe to very severe COP… TEMPRANO ANRS 12136 Study Group. 390(10107):2063-72. Accessed: 2018 Jun 4. 379(9835):2439-48. Callebaut C, Stepan G, Tian Y, Miller MD. EMA. [Medline]. Modified from an original published by Lohse et al (2007), "Survival of persons with and without HIV infection in Denmark, 1995-2005.". McColl DJ, Fransen S, Gupta S, et al. Doravirine versus ritonavir-boosted darunavir in antiretroviral-naive adults with HIV-1 (DRIVE-FORWARD): 48-week results of a randomised, double-blind, phase 3, non-inferiority trial. 276:23213-23216. Cell. [Medline]. Therefore, LABA and LAMA act cooperatively by reciprocally potentiating their bronchodilating effects. 44:23-33. Sax PE, Pozniak A, Montes ML, et al. Sept 2012. 14:762-766. Drugs. White K, Niedziela-Majka A, Novikov N, et al. Accessed: December 2, 2008. ACID‐BASE CONFERENCE. J Acquir Immune Defic Syndr. HIV-1 integrase: a target for new AIDS chemotherapeutics. [Full Text]. Preexposure prophylaxis for HIV infection among African women. Available at http://www.hiv.gov/hiv-basics/overview/data-and-trends/statistics. N Engl J Med. [Medline]. [Full Text]. [Medline]. HIV Clin Trials. Raritan, NJ: Merck & Co., Inc. May 2008. Pocket Guide to COPD Diagnosis, Management and Prevention [Internet] Fontana, WI The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 [Cited 12/04/2020] Available from: World Health Organization's List of Essential Medicines, "Tiotropium (Braltus) 10mcg Inhalation Powder - Summary of Product Characteristics (SmPC)", "Tiotropium Bromide Monograph for Professionals", https://goldcopd.org/wp-content/uploads/2020/03/GOLD-2020-POCKET-GUIDE-ver1.0_FINAL-WMV.pdf, "Follow-Up to the October 2008 Updated Early Communication about an Ongoing Safety Review of Tiotropium (marketed as Spiriva HandiHaler)", "Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials", "Tiotropium, a Novel Muscarinic M3 Receptor Antagonist, Improved Symptoms of Chronic Obstructive Pulmonary Disease Complicated by Chronic Heart Failure", "A systematic review of comparative studies of tiotropium Respimat® and tiotropium HandiHaler® in patients with chronic obstructive pulmonary disease: does inhaler choice matter? Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections, Boston, MA. 22:1399-1410. 2007. Abstracts from the 2017 Conference on Retroviruses and Opportunistic Infections. 2017; Accessed: 2018 Jun 20. Cooper RD, Wiebe N, Smith N, Keiser P, Naicker S, Tonelli M. Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients. 44:175-186. AIDS. Available at https://aidsinfo.nih.gov/news/2109/recommendations-regarding-the-use-of-dolutegravir-in-adults-and-adolescents-with-hiv-who-are-pregnant-or-of-child-bearing-potential. Sax PE, DeJesus E, Mills A, Zolopa A, Cohen C, Wohl D, et al. 2013 Jul 2. 2015 Aug 1. Misty M Miller, PharmD, BCPS, AAHIVP Associate Professor, University of Oklahoma Health Sciences Center College of Pharmacy [Guideline] Panel on Antiretroviral Guidelines for Adults and Adolescents. HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). [Medline]. Antiviral Drugs Advisory Committee, August 8, 2007. [Medline]. Available at http://www.eacsociety.org/files/guidelines_9.0-english.pdf. Powis KM, Kitch D, Ogwu A, Hughes MD, Lockman S, Leidner J, et al. [Medline]. Abstract 8. [Guideline] World Health Organization. 278:646-50. Ledipasvir and sofosbuvir for HCV in patients coinfected with HIV-1. 2017 Sept. Cohen CJ, Molina JM, Cassetti I, et al. [Medline]. 2018 Mar 7; Accessed: 2018 Jun 20. Gallant J, Brunetta J, Crofoot G, et al. 1999. 1994. Available at http://clinicaltrials.gov/ct2/show/NCT00707733. 47:1570-1579. [Medline]. 2010 Sep 1. [Full Text]. Warnke D, Barreto J, Temesgen Z. Antiretroviral drugs. AIDSinfo. Clin Ther. Puhan MA, Van Natta ML, Palella FJ, Addessi A, Meinert C, Ocular Complications of AIDS Research Group. 89:263-273. J Hepatol. J Acquir Immune Defic. Science. Clavel F, Hance AJ. GOLD guidelines recommend combining long-acting bronchodilators with differing mechanisms of action if the control of COPD is insufficient with monotherapy, and recent years have seen growing interest in the additional benefits that combination of long-acting muscarinic antagonists (LAMAs), typified by tiotropium, with long-acting β2-agonists (LABAs), such as formoterol and … 373(8):705-13. [Medline]. Resistance and cross-resistance to first generation integrase inhibitors: insights from a phase II study of elvitegravir (GS-9137). [Guideline] CDC/DHHS. [Medline]. Comparison of the sensitivities of primary isolates of HIV type 2 and HIV type 1 to antiviral drugs and drug combinations. 5 (5):e211-e220. Virologic failure of high-dose raltegravir with concomitant rifampin. Steigbigel RT, Cooper DA, Kumar PN, et al. Ann Intern Med. 352:48-62. Search ADS. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infections. 2007. Walmsley S, Antela A, Clumeck N, et al. Soriano V, Massimo P, Peters M, et al. 73(3):294-8. Anglemyer A, Rutherford GW, Egger M, Siegfried N. Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Global tuberculosis report 2017. WHO. Foster City, CA: Gilead Sciences. Fettiplace A, Stainsby C, Winston A, et al. Lalezari JP, Henry K, O'Hearn M, et al. [Medline]. 35:1657-1663. 2012. [Medline]. Effects of boosted tipranavir and lopinavir on body composition, insulin sensitivity and adipocytokines in antiretroviral-naive adults. Cochrane Database Syst Rev. Available at https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2017.pdf. [Medline]. AIDS. Pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors. Research has shown that when compared to placebo, montelukast provided relief of symptoms that was similar to loratadine (Claritin), yet less relief than provided with nasal inhaled steroids. Some additional information from Goodman & Gilman's Anticholinergic Agents With the advent of inhaled beta adrenergic agonists, use of anticholinergic CDC. Antiretroviral prophylaxis for HIV infection in injection drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomized, double-blind, placebo-controlled phase 3 trial. [Medline]. [Medline]. [73, 74]. 44:6-9. Rarely (<0.1% of patients) treatment is associated with: urinary retention, constipation, acute angle closure glaucoma, palpitations (notably supraventricular tachycardia and atrial fibrillation) and allergy (rash, angioedema, anaphylaxis). [Full Text]. [21], C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.[Br-], C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C. InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H/q+1;/p-1/t11?,12-,13+,16-,17+; InChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11?,12-,13+,16-,17-/m0/s1. 379(9835):2429-38. Torriani FJ, Rodriguez-Torres M, Rockstroh JK, et al. 365(6):493-505. [Medline]. 15(7):793-802. 338:853-60. PLoS One. 2011 Aug. 204(4):506-14. [Medline]. In vitro resistance profile of TMC278, a next-generation NNRTI; evidence of a higher genetic barrier and a more robust resistance profile than first generation NNRTIs. 2008. 2017 Nov. U.S. Food & Drug Administration. 2007. [Medline]. Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis. 27(6):939-50. Since then, the journal has published 18 … 43:291-310. 2012 Jul 20. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. Miller MM, Kinney KK, Liedtke ML. 1998. Tiotroprium is available in two inhaler formats: a soft mist inhaler (Respimat) and a dry powder inhaler (HandiHaler). Daar E, DeJesus E, Ruane P, et al. Whitehouse Station, NJ: Merck & Co, Inc. 2017 May. Nat Med. Common adverse drug reactions (≥1% of people) include: dry mouth and/or throat irritation. 2018 Jun 18. different mechanism of action can overcome specific patient dissimilarities in the response to different treatments ( Cazzola and Molimard, 2010 ), which may be due to different distribution [Guideline] Gunthard HF, Saag, MS, Benson CA, et al. 2002. Available at https://www.ema.europa.eu/docs/en_GB/document_library/.../WC500197861.pdf. … Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors. Daklinza (daclatasvir) tablets [package insert]. Lancet. The dual bronchodilator QVA149 (combination of indacaterol [LABA] and glycopyrronium [LAMA]) have been shown to reduce all exacerbation events (mild, moderate, and severe) to a greater degree than both tiotropium and glycopyrronium (24), presumably due to more effective reduction of hyperinflation with dual bronchodilation. Raltegravir with optimized background therapy for resistant HIV-1 infection. [Medline]. 385 (9987):2606-15. Available at http://www.unaids.org/en/resources/fact-sheet. [6] In 2017, it was the 82nd most commonly prescribed medication in the United States, with more than nine million prescriptions. Staci M Lockhart, PharmD, BCPS (AQ-ID) is a member of the following medical societies: American College of Clinical Pharmacy, Infectious Diseases Society of America, Phi Kappa Phi, Society of Infectious Diseases PharmacistsDisclosure: Nothing to disclose. 2011 May 11. Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug ReferenceDisclosure: Nothing to disclose. Available at http://www.who.int/hiv/pub/arv/arv-2016/en/. 2018 May 18; Accessed: 2018 Jun 27. Presented at the 2017 Conference on Retroviruses and Opportunistic Infections. The traditional approach has always been a combination therapy of LABA plus an inhaled corticosteroid. [Medline]. ... Several mechanisms of action have been postulated to be involved in the synergy between LABAs and LAMAs at the level of the presynaptic parasympathetic fibers and ASM cells [10, 13]. 348:2175-2185. [4] Severe side effects may include angioedema, worsening bronchospasm, and QT prolongation. 2018 Aug 1. Molina JM, Ward D, Brar I, et al. N Engl J Med. 2007. 351:438-450. Measuring Effects and Outcomes. Al-Bari. Virtual Issues. Weller IV, Williams IG. 2017 Jan 1. Section: In COPD, FEV 1 is used in diagnosis and staging, arterial blood gases are useful in defining respiratory failure, … 2016 Nov. 1(3):196-206. UNAIDS. FDA drug safety communication: FDA warns about the risk of hepatitis B reactivating in some patients treated with direct-acting antivirals for hepatitis C. Available at https://www.fda.gov/drugs/drugsafety/ucm522932.htm. Thio CL, Seaberg EC, Skolasky R Jr, et al. JAMA. Lancet. Pharmacokinetic enhancement of protease inhibitor therapy. 2012 Jun 30. Stellbrink HJ, Orkin C, Arribas JR, Compston J, Gerstoft J, Van Wijngaerden E. Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients. [Medline]. [Medline]. Van Damme L, Corneli A, Ahmed K, et al. Although Robert Wise, professor at John Hopkins University’s Division of Pulmonary and Critical Care Medicine, noted at the R&D day that “every time we add a bronchodilator, there is an improvement in lung function,” as LABA and LAMA have different mechanisms of action, and that “three drugs work better than two,” unfortunately, two in three patients remain symptomatic following … Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489): a double-blind, multicentre, phase 3, randomised controlled non-inferiority trial. However, it is only recently that the mechanisms leading to synergistic interactions have been experimentally elucidated … 2008. These positive pharmaco- logical interactions can be further amplified by the differ-ent distribution … [Medline]. New Mechanisms of Drug Action. Kontorinis N, Dieterich D. Toxicity of non-nucleoside analogue reverse transcriptase inhibitors. Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials. Combinations of LABA/LAMA bronchodilators with differing mechanisms of action produce a synergic increase in bronchodilation. 2014 Aug 1. Leukotriene modifiers (leukotriene antagonists) are medicines used to manage allergic rhinitis or allergies, as well as prevent asthma. N Engl J Med. ", Beclometasone/formoterol/glycopyrronium bromide, Budesonide/glycopyrronium bromide/formoterol, Fluticasone furoate/umeclidinium bromide/vilanterol, Indacaterol/glycopyrronium bromide/mometasone, Octatropine methylbromide (anisotropine methylbromide), Scopolamine butylbromide (hyoscine butylbromide), Nicotinic acetylcholine receptor modulators, Acetylcholine metabolism/transport modulators, https://en.wikipedia.org/w/index.php?title=Tiotropium_bromide&oldid=1000347557, World Health Organization essential medicines, Chemical articles with unknown parameter in Infobox drug, Infobox drug articles with non-default infobox title, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple PubChem CIDs, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Creative Commons Attribution-ShareAlike License, This page was last edited on 14 January 2021, at 19:10. J Infect Dis. J Biol Chem. 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