This stage is also called the “avascular stage” as the blood supply to alveoli gets decreased. Get immunized: Vaccinate your baby against most common pathogens responsible for pneumonia i.e. H1N1 pneumonia (swine influenza) H5N1 pneumonia (avian influenza) paramyxoviridae ❷ Smoking: Smoking slows down ciliary movements and natural defense mechanism against bacteria and viruses. Other medicines include levofloxacin and amoxicillin. It further causes fever, cough, and creates difficulty in breathing. Endovascular (inside the blood vessel) infection. Currently, no vaccine exists to effectively combat this virus and treatments are widely ineffective with potentially hazardous side effects. Other risk factors include smoking, taking steroids, and hospitalization. Recently a study was conducted on COVID-19 Patients with Multifocal Pneumonia. Save my name, email, and website in this browser for the next time I comment. The microorganism can reach your lungs by the following routes: 4. Finally, either it resolves or ends up with adhesion (sticking together) of the pleural membrane. Stop sharing objects: As infection can be spread through the contaminated objects so, it is best to avoid sharing utensils or any personal objects with others. Inhalation of a hefty dose of fungi present in the soil or in the birds infected droppings can make you ill. ❸ Viruses: Viruses, including COVID-19, are associated with multifocal Pneumonia. Welcome to your trusted online source for scientific evidence based latest health information… We are dedicated to provide you the very best of our text, graphics, images, and other health-materials with a focus on grooming your health, wellness and fitness. Different stages of Multifocal Pneumonia include 1) Congestion, 2) Red hepatization, 3) Grey hepatization, and 4) Resolution. The prescription was prepared by a 503A custom compounding pharmacy that has extensive experience with this formula. If “YES,” then you should not ignore these symptoms. Most of the patients had multifocal (89.1%) and bilateral (86.4%) lesions. 3. Sig: Nebulize 1 mL Quercetin (200 mg/mL) and 1 mL NAC (100 mg/mL) to be combined in a nebulizer reservoir and breathing treatment done in full mask nebulization three times per day. Introduction. Mark, in Diagnostic Pathology of Infectious Disease (Second Edition), 2018. If anyone touches these contaminated objects or surfaces, germs get transferred to them. DP and JO have full access to all the patient’s records and data for these case histories and accept full responsibility for the integrity and accuracy of the data as presented. Small blood vessels (capillaries) surrounding alveolar walls become congested. 03/26/2020 on Left, 04/24/2020 on Right. Currently the formula can be ordered by prescription via compounding pharmacies. Its severity ranges from mild with minimal symptoms to severe life-threatening conditions. Pneumonia is an infection that causes inflammation in one or both of the lungs. In the case of the patient mentioned in this study, the decision was made to administer treatment at home because of ease of use and conscious decision not to expose any of our high-risk cancer and chronic disease patients to possible COVID-19 contagion in clinic. Cough, sneezes, or exhalation by an infected person can release a burst of micro air-droplets (aerosol) in the environment. He was asked to continue azithromycin 500 mg and Hydroxychloroquine 200 mg twice a day. People with old-age groups and chronic diseases can also get benefited with the vaccination. Patient Response: COVID-19 positive Multifocal Pneumonia. At home, he explained that he felt as though he was only able to use about 60% of his breathing capacity and difficulty taking deep breaths. Alveolar air sacs gets filled with secreted fluids. Do you have breathing difficulty, fever, or cough? No active cardiopulmonary abnormalities. Atypical pneumonia makes up a significant proportion of community-acquired pneumonia. Quercinex is a nebulizer treatment consisting of a formula with quercetin and NAC as its active ingredients. no pulmonary fibrosis (scarring). It can develop from flu or another infection that affects the lungs. After two days of Quercinex treatment, the patient reported that his lung function continued to significantly improve. In cell cultures, quercetin has been shown by research to impede viral replication and reduce the infectivity of viruses, possibly through the mechanism of binding to viral capsid proteins, induction of interferon, or inhibition of DNA gyrase and DNA proteases [11]. Endocarditis (infection of the inner wall of the heart), 3. Potential adverse reactions from quercetin include tingling of extremities and headache for oral use; and flushing, sweating, nausea, vomiting, and injection site pain after infusion for IV [12]. Pulmonary infarction (death of tissues due to low blood supply), 4. Symptoms include chest pain, cough, breathing difficulty, and fever. All other possible side effects are considered mild. Our website services, content, and products are for informational purposes only. Rhodococcus pneumonia is a zoonotic infection that causes a nodular histiocytic and cavitary pneumonia in immunosuppressed patients, most commonly with HIV/AIDS (Fig. They were treated with Hydroxy-chloroquine which showed good improvement in their health condition. On behalf of all authors, Dino Prato NMD is founder and CEO of Envita Medical Centers and Developer of Quercinex formulation. The patient was positive for COVID-19, which was the attributed cause of the bilateral, multifocal pneumonia. Antibiotics are not effective in treating viruses. As an additional detail, within the first two days of the nebulizer treatment, the patient had improved so greatly that he reported being able and inclined to build a gym in his garage. It is important to note that no pulmonary fibrosis was seen in the patient’s lungs post COVID-19 bilateral pneumonia treatment with Quercinex when compared with pre-Quercinex treatment (Figure 4). Uses over the counter medications for fever and pain. 1. Younger and older age groups, weak immunity, smoking, hospitalization, and chronic diseases are the significant risk factors for developing Pneumonia. It occurs within the next 2-3 days after the congestion stage. Elderly persons are at increased risk of infection and complications in viral pneumonia because of comorbidities. With IV infusions > 945 mg/m2 Nephrotoxicity can occur [12]. The main types of pneumonia are bacterial, viral, and mycoplasma pneumonia. The symptoms of COVID-19 pneumonia may be similar to other types of viral pneumonia.Because of this, it can be difficult to tell what’s causing your condition without being tested for … nebulized Quercenix treatment three times a day for 14 days as adjuvant therapy. The inexpensiveness and ease of production of both quercetin and NAC lends itself to potential widescale distribution if the formula is found to be effective in other large-scale studies. The non-toxic, inexpensive and safe nature of the agent warrants its consideration as adjuvant treatment for COVID-19 respiratory symptoms. Your lungs become swollen and cannot work well. The FDA has recommended that hydroxychloroquine only be used in a hospital setting because of potential heart rhythm problems [1]. It begins with cold or flu and then further progresses as Pneumonia. What are the Differential Diagnosis of Multifocal Pneumonia? Children, old age group people, and people with weakened immunity are the primary target for severe illness. When the infective organism reaches your lower respiratory tract i.e., lungs and alveoli, you may develop multifocal pneumonia. Direct infection from the adjacent lung area. Scientific Research Managing symptoms of upper respiratory viral infections early is critical, both for patient outcomes and sparing healthcare resources for sicker patients. So let’s have a look further with us. Figure 3. But bacteria, fungi, and other microorganisms can also cause it. Our respiratory system consists of organs that helps in the exchange of oxygen and carbon dioxide from the blood. The middle part of the lungs, which acts as an attachment for lungs root and from where structures(airway, blood vessels, nerves) enter and exit is called hilum. Blood tests are used to confirm an infection and to try to identify the type of organism causing the infection. ❹ Weak immune system: People with organ transplants, receiving chemotherapy, taking steroids for a long term, or having HIV/AIDS have low immunity. Viral pneumonia in elderly persons. ❝There is one consolation in being sick, and that is the possibility that you may recover to a better state than you were ever in before.❞. Secretion contains blood cells such as neutrophil, lymphocytes, fibers, and proteins. After finishing the protocol, the patient has not reported any sensation of shortness of breath since. A total of 480,401 deaths due to COVID-19 was reported by WHO till present we are writing this article. VAP is pneumonia which occurs after at least 48 hours of intubation and mechanical ventilation. It reduces up to 50-90% chances of getting infected. 2. Pathology. A variety of organisms, including bacteria, viruses and fungi, can cause pneumonia.Pneumonia can range in seriousness from mild to life-threatening. It progresses with different stages which is called “stages of pneumonia.”. Envita Medical Center has many years of experience using both Quercetin and NAC separately. The nebulized mist of the Quercinex potentially blocks the invasion of the virus with a non-toxic and safe adjuvant antiviral therapy directly to the respiratory tissue under attack, and for this reason we feel it to be clinically relevant for care during this crisis, and more importantly, for future research. 4. Blood tests. influenza pneumonia. 30 - 50 mg of any form of zinc once daily by mouth to prevent from Zinc deficiency. Treatment of Multifocal Pneumonia include symptomatic management, supportive treatment and specific treatment to control viral or bacterial infection. Quercinex was prescribed by Envita’s doctors (via 503A compounded pharmacy prescriptions) as an adjuvant to the current standard of care recommendations for COVID-19. Especially if when you are admitted to ICCU and on a mechanical breathing machine (ventilator). Fibrinous inflammation of pleural space (space between two layers of tissue surrounding the lungs) causes a rubbing sound on auscultation. He leads us to believe that for doses used in this protocol, the potential for complications is extremely low, and no further complications are anticipated. It helps to prevent the spread of infection, including COVID-19. Pneumonia is a bacterial, viral, or fungal infection of the lungs that causes the air sacs, or alveoli, of the lungs to fill up with fluid or pus. Multifocal pneumonia spreads though the following 4 routes: inhalation (most common route), aspiration, haematogenous spread, and through the direct infection from the adjacent lung areas. Molecular diagnostic tests have greatly increased our understanding of the role of viruses in pneumonia, and findings indicate that the incidence of viral pneumonia has been underestimated. Both of these micro-organisms are contagious and spread by close contact. We are publishing this case study now to illuminate the effect the combined formula has had on a confirmed case of COVID-19. Antibiotics are not effective in treating viruses. What are the Different Components of the Respiratory System? Infections and toxic exposure to lungs initiate the inflammatory reactions that cause pain, swelling, and fluid secretions. Multifocal Pneumonia is defined as the ” Inflammation in multiple areas of one or both of the lungs, caused by bacterial or viral infection, in which the air sacs gets filled with the pus and becomes solid.” Primary symptoms are breathing difficulty, chest pain, cough, and fever. Even patients who have been successfully treated and have fully recovered may face long-term health issues. They can be caused by any of a large number of viral agents, including but not limited to: RNA viruses. The treatment is directly administered to the lungs where the ACE2 receptors on Type II pneumocytes are located and the Coronavirus spike proteins favor infiltration, invasion and, replication within the respiratory system [21]. Sudden-onset hemoptysis and dyspnea developed; all 3 patients and died <12 h later of massive pulmonary bleeding, despite aggressive supportive care. Both Quercetin and NAC have been nebulized separately and administered to patients at Envita Medical Center over several years. Copyright © 2020 by authors and Scientific Research Publishing Inc. All the agents in this protocol are substances that are considered generally safe at these doses. Forget the hassle and nurture your inbox with health and wellness advice that’s inclusive and rooted in medical expertise. Viral respiratory tract infection is a broad term given to pulmonary infection caused by viruses. NAC is an FDA approved agent used for the treatment of acetaminophen overdose and to loosen thick mucus in individuals with cystic fibrosis or chronic obstructive pulmonary disease [4] [5] [13]. ❺ Chronic disease: Chronic lungs and heart diseases such as asthma, chronic obstructive pulmonary disease (COPD) makes you prone to develop Pneumonia. It usually begins with mild cold or flu and primarily affects children aging less than 5 years of age. Sociodemographic and clinical characteristics of the patient can be viewed in (Table 1). Quercinex has been observed by Envita’s Doctors to be clinically safe and non-toxic with a proposed mechanism that could enhance other drug regimens or to act on its own to improve clinical outcomes significantly. Cyclodextrin is a non-active ingredient in Quercinex. Alveolar capillaries or tiny blood vessels gets swollen due to excessive blood. Your email address will not be published. Sunita Aind an Author & blogger, inspired by health and living. But Celia stops working due to certain diseases and cigarette smoking. Figure 4. Envita Medical Center put together the Quercinex formula after many years of observing the effects of nebulized and intravenous quercetin and NAC separately. HAP occurs 48 hours or more after being admitted to the hospital. "Bilateral" means that the infection is present in both lungs. For treatment and its prevention, it is essential to know about its causative factors. The rapid clinical improvement in this case may suggest a helpful clinical adjuvant via nebulization if the treatment is performed in an open-air environment, conscious of the risk of corona virus spreading through nebulized particles. 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